The theory of arterial acceleration is a fundamentally new view on how the cardiovascular system promotes oxygen enriched blood to reach all the bodies capillary systems. It also provides a new perspective on pulsatile signals such as the arterial blood pressure, measured invasively or non-invasively, and blood flow (velocities) in the brain or elsewhere in the body. The theory of arterial acceleration proposes that systole consists of two phases, the first being the result of a short-lasting stiffening of the smooth muscle layers in the arterial tree, the second being the result of stroke volume being ejected into the aorta and large capacitance arteries.
Neuromon BV strives to popularise the theory of arterial acceleration since it is expected that this novel approach to signal interpretation will katalyse new insights in cardio-vascular (patho-)physiology and, thus, therapy. More knowledge of the theory of arterial acceleration seems most relevant for ICU-specialists since they carry the daily responsibility for severely ill patients on the ICU.
Apart from educational video's to be found on the internet Neuromon also offers an interactive education course via videoconferencing. This course consists of 6 modules:
1. introduction to the course; introduction to transcranial Doppler
2. introduction to the measurement of arterial blood pressure; the CNS ischemic response
3. current theories on wave form characteristics; theory of arterial acceleration
4. TCD monitoring; effect of ageing on pulsatile signals
5. baroceptor and chemoceptor reflex; model for cardiovascular simulation
6. clinical cases such as carotid stenosis and sepsis; history of conceptual thinking about arterial blood pressure
The modules have a duration of approximately 30 min. each and will be presented online on a weekly basis. Each module will end with approximately 15 minutes of discussion. The subscription for the full course amounts Euro 200. After actively participating in all six modules, you will receive a formal certificate testifying your participation.
Recently, a video was released discussing how the theory of arterial acceleration is part of the ongoing scientific quest for a better understanding of cardiovascular physiology. This quest started with Galen in the 2nd century, is greatly furthered by Harvey in the 17th century as well as by various investigators at the end of the 19th century. The theory of acceleration adds to conceptual thinking about the role of the arterial system in cardiovascular physiology. It challenges a too simplistic view on arterial blood pressure.
In a joint effort DWL and Neuromon B.V. have recently made the new TCD parameters available for current and future DWL customers. In the latest QL software signal analysis based upon the new TCD parameters is optionally available. It can be acquired via the DWL distributors network. The new TCD parameters significantly enhance signal analysis and interpretation. Please refer to relevant literature.
This app intends to bridge the gap between middle cerebral artery flow velocity parameterisation and clinical interpretation. Basically, sys1, sys2, dias@560 and HR are converted to so-called Z-scores that correct for the effects of ageing.
Based upon published observations the Z-scores are used for clinical interpretation. Of course, Neuromon BV cannot take the responsibility for clinical decision making and the NMA app should only be seen as support in the process. Treating physicians should always remain vigilant and not use information from the NMA alone to interpret the clinical condition of a patient. Nevertheless, the NMA module brings a new approach to patient assessment on the ICU based upon a new philosophy on cardiovascular physiology.
Find your NMA in the Appstore via this link NMA or alternatively by searching "NMA TCD".
Neuromon has prepared 6 presentations of 8 to 13 minutes explaining the theoretical background behind the model for cardiovascular simulation. This model was originally developed in Labview™ in collaboration with Annika de Goede from the TUTwente. It was subsequently translated to C# by Neuromon. After registration, the model can be downloaded from the web page.
The model of cardiovascular simulation should be seen as an illustration of theoretical concepts in cardiovascular physiology. It includes the CNS ischemic response, the theory of arterial acceleration and cardiovascular reflexes such as auto regulation, the baroceptosr reflex the chemoreceptor reflex and the Bainbridge reflex.
Incorporating different physiological responses into a single computer simulation helps to understand the complex interplay of all these responses combined. A computer simulation should be seen as an illustration of the theory. It is based upon simple mathematical rules that joined together become a system of high complexity. A model as this, however, can never live up to the complexity of cardiovascular physiology in real life.
The 6 presentations can be found on the web page for theoretical background.
Alternatively, a link to the first presentation can be found below.